Petromurin C Induces Protective Autophagy and Apoptosis in FLT3-ITD-Positive AML: Synergy with Gilteritinib

Petromurin C Induces Protective Autophagy and Apoptosis in FLT3-ITD-Positive AML: Synergy with Gilteritinib

Treatment of acute myeloid leukemia (AML) remains inefficient due to drug resistance and relapse, particularly in patients with FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD). Marine-derived natural products have recently been used for drug development against AML. We show in th...

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Bibliographic Details
Main Authors: You Na Ha, Sungmi Song, Barbora Orlikova-Boyer, Claudia Cerella, Christo Christov, Anake Kijjoa, Marc Diederich
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Marine Drugs
Subjects:
acute myeloid leukemia
<i>aspergillus candidus</i>
<i>epipolasis</i> sp.
cell death
mitochondrial stress
combination treatment
Online Access:https://www.mdpi.com/1660-3397/18/1/57

Internet

https://www.mdpi.com/1660-3397/18/1/57

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