Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion

Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion

The aim of this study was to improve the physicochemical properties of cocoa extract (CE) using hot-melt extrusion (HME) for pharmaceutical proposes. A mixture design was applied using three distinct hydrophilic polymeric matrices (Soluplus, Plasdone S630, and Eudragit E). Systems obtained by HME we...

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Bibliographic Details
Main Authors: Ludmila A. G. Pinho, Saulo G. Souza, Ricardo N. Marreto, Livia L. Sa-Barreto, Tais Gratieri, Guilherme M. Gelfuso, Marcilio Cunha-Filho
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Pharmaceutics
Subjects:
hot-melt extrusion
cocoa extract
mixture design
flowability
dissolution rate
Online Access:http://www.mdpi.com/1999-4923/10/3/135

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http://www.mdpi.com/1999-4923/10/3/135

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