Identification of a novel role of IL-13Rα2 in human Glioblastoma multiforme: interleukin-13 mediates signal transduction through AP-1 pathway

Identification of a novel role of IL-13Rα2 in human Glioblastoma multiforme: interleukin-13 mediates signal transduction through AP-1 pathway

Abstract Background Previously, we have demonstrated that Interleukin 13 receptor alpha 2 (IL-13Rα2) is overexpressed in approximate 78% Glioblastoma multiforme (GBM) samples. We have also demonstrated that IL-13Rα2 can serve as a target for cancer immunotherapy in several pre-clinical and clinical...

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Bibliographic Details
Main Authors: Rukmini Bhardwaj, Akiko Suzuki, Pamela Leland, Bharat H. Joshi, Raj K. Puri
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Translational Medicine
Subjects:
Glioblastoma
AP-1
Transcription factors
IL-13
IL-13Rα2
Online Access:http://link.springer.com/article/10.1186/s12967-018-1746-6

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http://link.springer.com/article/10.1186/s12967-018-1746-6

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