HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured IM-9 cells

HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured IM-9 cells

The activity of HMG-CoA reductase (HMGR) is tightly regulated, in part through post-transcriptional mechanisms that are mediated by nonsterol products of mevalonate metabolism. Previous reports have suggested that these mediators are derived from farnesyl pyrophosphate (FPP). Recent studies have imp...

Full description

Bibliographic Details
Main Authors: Stephen F. Petras, Saralyn Lindsey, H. James Harwood, Jr.
Format: Article
Language:English
Published: Elsevier 1999-01-01
Series:Journal of Lipid Research
Subjects:
cholesterol synthesis
HMG-CoA reductase
squalene synthetase
enzyme inhibition
metabolic regulation
cultured cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520333368

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520333368

Similar Items