Evidence for evolutionary and nonevolutionary forces shaping the distribution of human genetic variants near transcription start sites.

The regions surrounding transcription start sites (TSSs) of genes play a critical role in the regulation of gene expression. At the same time, current evidence indicates that these regions are particularly stressed by transcription-related mutagenic phenomena. In this work we performed a genome-wide...

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Bibliographic Details
Main Authors: Giovanni Scala, Ornella Affinito, Gennaro Miele, Antonella Monticelli, Sergio Cocozza
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4256220?pdf=render