Mutagenesis Induced by Sub-Lethal Doses of Ciprofloxacin: Genotypic and Phenotypic Differences Between the Pseudomonas aeruginosa Strain PA14 and Clinical Isolates

Mutagenesis Induced by Sub-Lethal Doses of Ciprofloxacin: Genotypic and Phenotypic Differences Between the Pseudomonas aeruginosa Strain PA14 and Clinical Isolates

Bacterial resistance is a severe threat to global public health. Exposure to sub-lethal concentrations has been considered a major driver of mutagenesis leading to antibiotic resistance in clinical settings. Ciprofloxacin is broadly used to treat infections caused by Pseudomonas aeruginosa, whereas...

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Bibliographic Details
Main Authors: Letícia Busato Migliorini, Holger Brüggemann, Romario Oliveira de Sales, Paula Célia Mariko Koga, Andrea Vieira de Souza, Marines Dalla Valle Martino, Rodrigo S. Galhardo, Patricia Severino
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Microbiology
Subjects:
Pseudomonas aeruginosa
bacterial resistance
umuDC
ciprofloxacin
induced mutagenesis
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01553/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.01553/full

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