PD-1 in human NK cells: evidence of cytoplasmic mRNA and protein expression

PD-1 in human NK cells: evidence of cytoplasmic mRNA and protein expression

Under physiological conditions, PD-1/PD-L1 interactions regulate unwanted over-reactions of immune cells and contribute to maintain peripheral tolerance. However, in tumor microenvironment, this interaction may greatly compromise the immune-mediated anti-tumor activity. PD-1+ NK cells have been dete...

Full description

Bibliographic Details
Main Authors: Francesca R. Mariotti, Stefania Petrini, Tiziano Ingegnere, Nicola Tumino, Francesca Besi, Francesca Scordamaglia, Enrico Munari, Silvia Pesce, Emanuela Marcenaro, Alessandro Moretta, Paola Vacca, Lorenzo Moretta
Format: Article
Language:English
Published: Taylor & Francis Group 2019-03-01
Series:OncoImmunology
Subjects:
natural killer cells
checkpoint inhibitors
pd-1
cd56dim cd56bright
mrna isoforms
pd-1 cytoplasmic pool
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1557030

Internet

http://dx.doi.org/10.1080/2162402X.2018.1557030

Similar Items