Prevention of P2 Receptor-Dependent Thrombocyte Activation by Pore-Forming Bacterial Toxins Improves Outcome in a Murine Model of Urosepsis

Prevention of P2 Receptor-Dependent Thrombocyte Activation by Pore-Forming Bacterial Toxins Improves Outcome in a Murine Model of Urosepsis

Urosepsis is a potentially life-threatening, systemic reaction to uropathogenic bacteria entering the bloodstream of the host. One of the hallmarks of sepsis is early thrombocyte activation with a following fall in circulating thrombocytes as a result of intravascular aggregation and sequestering of...

Full description

Bibliographic Details
Main Authors: Mette G. Christensen, Nanna Johnsen, Marianne Skals, Aimi D. M. Hamilton, Peter Rubak, Anne-Mette Hvas, Helle Praetorius
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
P2Y<sub>1</sub>
P2Y<sub>12</sub>
sepsis
<i>Escherichia</i> <i>coli</i>
HlyA
thrombocytes
Online Access:https://www.mdpi.com/1422-0067/21/16/5652

Internet

https://www.mdpi.com/1422-0067/21/16/5652

Similar Items