Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance.

Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance.

Altered insulin secretion contributes to the pathogenesis of type 2 diabetes. This alteration is correlated with altered intracellular Ca(2+)-handling in pancreatic β cells. Insulin secretion is triggered by elevation in cytoplasmic Ca(2+) concentration ([Ca(2+)]cyt) of β cells. This elevation in [C...

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Bibliographic Details
Main Authors: Sayali S Dixit, Tiannan Wang, Eiffel John Q Manzano, Shin Yoo, Jeongkyung Lee, David Y Chiang, Nicole Ryan, Jonathan L Respress, Vijay K Yechoor, Xander H T Wehrens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3596297?pdf=render

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http://europepmc.org/articles/PMC3596297?pdf=render

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