Detection of Natural Resistance-Associated Substitutions by Ion Semiconductor Technology in HCV1b Positive, Direct-Acting Antiviral Agents-Naïve Patients

Detection of Natural Resistance-Associated Substitutions by Ion Semiconductor Technology in HCV1b Positive, Direct-Acting Antiviral Agents-Naïve Patients

Naturally occurring resistance-associated substitutions (RASs) can negatively impact the response to direct-acting antivirals (DAAs) agents-based therapies for hepatitis C virus (HCV) infection. Herein, we set out to characterize the RASs in the HCV1b genome from serum samples of DAA-naïve patients...

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Bibliographic Details
Main Authors: Nadia Marascio, Grazia Pavia, Alessio Strazzulla, Tim Dierckx, Lize Cuypers, Bram Vrancken, Giorgio Settimo Barreca, Teresa Mirante, Donatella Malanga, Duarte Mendes Oliveira, Anne-Mieke Vandamme, Carlo Torti, Maria Carla Liberto, Alfredo Focà, the SINERGIE-UMG Study Group
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:International Journal of Molecular Sciences
Subjects:
hepatitis C virus 1b
resistance-associated substitutions
direct-acting antiviral agents
deep-sequencing
Online Access:http://www.mdpi.com/1422-0067/17/9/1416

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http://www.mdpi.com/1422-0067/17/9/1416

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