Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures

SUMMARY The availability of animal models of epileptic seizures provides opportunities to identify novel anticonvulsants for the treatment of people with epilepsy. We found that exposure of 2-day-old zebrafish embryos to the convulsant agent pentylenetetrazole (PTZ) rapidly induces the expression of...

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Bibliographic Details
Main Authors: Sarah Baxendale, Celia J. Holdsworth, Paola L. Meza Santoscoy, Michael R. M. Harrison, James Fox, Caroline A. Parkin, Philip W. Ingham, Vincent T. Cunliffe
Format: Article
Language:English
Published: The Company of Biologists 2012-11-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/5/6/773