Temporal integration of mitochondrial stress signals by the PINK1:Parkin pathway

Temporal integration of mitochondrial stress signals by the PINK1:Parkin pathway

Abstract Background The PINK1:Parkin pathway regulates the autophagic removal of damaged and dysfunctional mitochondria. While the response of this pathway to complete loss of ΔΨm, as caused by high concentrations of mitochondrial ionophores, has been well characterized, it remains unclear how the p...

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Bibliographic Details
Main Authors: J. Logan Bowling, Mary Catherine Skolfield, Wesley A. Riley, Andrew P. Nolin, Larissa C. Wolf, David E. Nelson
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Molecular and Cell Biology
Subjects:
Cell signalling
Mitophagy
Parkin
PTEN-induced putative kinase 1 (PINK1)
Ubiquitin
Online Access:http://link.springer.com/article/10.1186/s12860-019-0220-5

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http://link.springer.com/article/10.1186/s12860-019-0220-5

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