Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice

Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice

The polyol pathway, which converts glucose into sorbitol and fructose, is active in chronic conditions like hepatic steatosis and chronic kidney disease. Here, Andres-Hernandoet al. show that fructose production promotes renal injury and fructokinase inhibition protects against kidney damage during...

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Bibliographic Details
Main Authors: Ana Andres-Hernando, Nanxing Li, Christina Cicerchi, Shinichiro Inaba, Wei Chen, Carlos Roncal-Jimenez, Myphuong T. Le, Michael F. Wempe, Tamara Milagres, Takuji Ishimoto, Mehdi Fini, Takahiko Nakagawa, Richard J. Johnson, Miguel A. Lanaspa
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14181

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https://doi.org/10.1038/ncomms14181

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