Synthesis and Cytotoxicity Evaluation of DOTA-Conjugates of Ursolic Acid

In this study, we report the synthesis of several amine-spacered conjugates of ursolic acid (UA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA). Thus, a total of 11 UA-DOTA conjugates were prepared holding various oligo-methylene diamine spacers as well as different substituents...

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Bibliographic Details
Main Authors: Michael Kahnt, Sophie Hoenke, Lucie Fischer, Ahmed Al-Harrasi, René Csuk
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/24/12/2254