Promoter methylation inhibits expression of tumor suppressor KIBRA in human clear cell renal cell carcinoma

Promoter methylation inhibits expression of tumor suppressor KIBRA in human clear cell renal cell carcinoma

Abstract Background KIBRA has been suggested as a key regulator of the Hippo signaling pathway, regulating organ size, cell contact inhibition, tissue regeneration as well as tumorigenesis and cystogenesis. We recently reported that human KIBRA expression depends on a complex alternative CpG-rich pr...

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Bibliographic Details
Main Authors: Katrin Schelleckes, Boris Schmitz, Giuliano Ciarimboli, Malte Lenders, Hermann J. Pavenstädt, Edwin Herrmann, Stefan-Martin Brand, Eva Brand
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Clinical Epigenetics
Subjects:
Epigenetics
Renal cancer
Hippo pathway
Methylation
Tumor
WWC1
Online Access:http://link.springer.com/article/10.1186/s13148-017-0415-6

Internet

http://link.springer.com/article/10.1186/s13148-017-0415-6

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