Inhibition of β2-microglobulin/hemochromatosis enhances radiation sensitivity by induction of iron overload in prostate cancer cells.

Inhibition of β2-microglobulin/hemochromatosis enhances radiation sensitivity by induction of iron overload in prostate cancer cells.

BACKGROUND:Bone metastasis is the most lethal form of several cancers. The β2-microglobulin (β2-M)/hemochromatosis (HFE) complex plays an important role in cancer development and bone metastasis. We demonstrated previously that overexpression of β2-M in prostate, breast, lung and renal cancer leads...

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Bibliographic Details
Main Authors: Sajni Josson, Yasuhiro Matsuoka, Murali Gururajan, Takeo Nomura, Wen-Chin Huang, Xiaojian Yang, Jin-Tai Lin, Roger Bridgman, Chia-Yi Chu, Peter A Johnstone, Majd Zayzafoon, Peizhen Hu, Haiyen Zhau, Dror Berel, Andre Rogatko, Leland W K Chung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3707913?pdf=render

Internet

http://europepmc.org/articles/PMC3707913?pdf=render

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