Minimal impact of ZAP on lentiviral vector production and transduction efficiency

Minimal impact of ZAP on lentiviral vector production and transduction efficiency

The antiviral protein ZAP binds CpG dinucleotides in viral RNA to inhibit replication. This has likely led to the CpG suppression observed in many RNA viruses, including retroviruses. Sequences added to retroviral vector genomes, such as internal promoters, transgenes, or regulatory elements, substa...

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Bibliographic Details
Main Authors: Helin Sertkaya, Laura Hidalgo, Mattia Ficarelli, Dorota Kmiec, Adrian W. Signell, Sadfer Ali, Hannah Parker, Harry Wilson, Stuart J.D. Neil, Michael H. Malim, Conrad A. Vink, Chad M. Swanson
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
retroviral vector
lentiviral vector
HIV-1
zinc-finger antiviral protein
ZAP
ZC3HAV1
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121001340

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http://www.sciencedirect.com/science/article/pii/S2329050121001340

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