Which pathways trigger the role of complement in ischaemia/reperfusion injury?

Investigations into the role of complement in ischaemia/reperfusion injury have identified common effector mechanisms that depend on the production of C5a and C5b-9 through the cleavage of C3. These studies have also defined an important role for C3 synthesised within ischaemic kidney. Less clear ho...

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Bibliographic Details
Main Authors: Conrad Anthony Farrar, Elham eAsgari, Wilhelm J Schwaeble, Steven eSacks
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-11-01
Series:Frontiers in Immunology
Subjects:
MBL
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00341/full