Imbalance of NET and Alpha-1-Antitrypsin in Tuberculosis Patients Is Related With Hyper Inflammation and Severe Lung Tissue Damage

Imbalance of NET and Alpha-1-Antitrypsin in Tuberculosis Patients Is Related With Hyper Inflammation and Severe Lung Tissue Damage

Background: Pulmonary tuberculosis (PTB) can lead to lung tissue damage (LTD) and compromise the pulmonary capacity of TB patients that evolve to severe PTB. The molecular mechanisms involved in LTD during anti-tuberculous treatment (ATT) remain poorly understood.Methods and findings: We evaluated t...

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Bibliographic Details
Main Authors: Mayla Gabryele Miranda de Melo, Eliene Denites Duarte Mesquita, Martha M. Oliveira, Caio da Silva-Monteiro, Anna K. A. Silveira, Thiago S. Malaquias, Tatiana C. P. Dutra, Rafael M. Galliez, Afrânio L. Kritski, Elisangela C. Silva, the Rede-TB Study Group
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
severe pulmonary tuberculosis
neutrophils
NET
alpha-1-antitripsin
hyperinflammation
biomarkers
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03147/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.03147/full

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