β-Adrenergic Receptor Stimulation and Alternans in the Border Zone of a Healed Infarct: An ex vivo Study and Computational Investigation of Arrhythmogenesis

β-Adrenergic Receptor Stimulation and Alternans in the Border Zone of a Healed Infarct: An ex vivo Study and Computational Investigation of Arrhythmogenesis

Background: Following myocardial infarction (MI), the myocardium is prone to calcium-driven alternans, which typically precedes ventricular tachycardia and fibrillation. MI is also associated with remodeling of the sympathetic innervation in the infarct border zone, although how this influences arrh...

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Bibliographic Details
Main Authors: Jakub Tomek, Guoliang Hao, Markéta Tomková, Andrew Lewis, Carolyn Carr, David J. Paterson, Blanca Rodriguez, Gil Bub, Neil Herring
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Physiology
Subjects:
myocardial infarction
β-adrenergic receptor
sympathetic nervous system
alternans
arrhythmias
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00350/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00350/full

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