A Direct Role for the CD1b Endogenous Spacer in the Recognition of a Mycobacterium tuberculosis Antigen by T-Cell Receptors

A Direct Role for the CD1b Endogenous Spacer in the Recognition of a Mycobacterium tuberculosis Antigen by T-Cell Receptors

Lipids, glycolipids and lipopeptides derived from Mycobacterium tuberculosis (Mtb) are presented to T cells by monomorphic molecules known as CD1. This is the case of the Mtb-specific sulfoglycolipid Ac2SGL, which is presented by CD1b molecules and is recognized by T cells found in tuberculosis (TB)...

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Bibliographic Details
Main Authors: Frank Camacho, Ernesto Moreno, Luis F. Garcia-Alles, Glay Chinea Santiago, Martine Gilleron, Aleikar Vasquez, Yee Siew Choong, Fátima Reyes, Mohd Nor Norazmi, Maria E. Sarmiento, Armando Acosta
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
CD1b
Mycobacterium tuberculosis
sulfoglycolipids
Ac2SGL
scTCR
endogenous spacer
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.566710/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.566710/full

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