Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum

Endoplasmic reticulum (ER) dysfunction is important for alpha-synuclein (αS) acquired toxicity. When targeted to the ER in SH-SY5Y cells, transient or stable expression of αS resulted in the formation of compact αS-positive structures in a small subpopulation of cells, resembling αS inclusions. Thus...

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Bibliographic Details
Main Authors: Fabiana Miraglia, Verdiana Valvano, Lucia Rota, Cristina Di Primio, Valentina Quercioli, Laura Betti, Gino Giannaccini, Antonino Cattaneo, Emanuela Colla
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Life
Subjects:
alpha-synuclein
oligomers
aggregation
endoplasmic reticulum
FRET
biosensors
Online Access:https://www.mdpi.com/2075-1729/10/8/147

Internet

https://www.mdpi.com/2075-1729/10/8/147

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