N-Glycans Mediate the Ebola Virus-GP1 Shielding of Ligands to Immune Receptors and Immune Evasion

N-Glycans Mediate the Ebola Virus-GP1 Shielding of Ligands to Immune Receptors and Immune Evasion

The Ebola Virus (EBOV) glycoprotein (GP) sterically shields cell-membrane ligands to immune receptors such as human leukocyte antigen class-1 (HLA-I) and MHC class I polypeptide-related sequence A (MICA), thus mediating immunity evasion. It was suggested that the abundant N-glycosylation of the EBOV...

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Bibliographic Details
Main Authors: Muhammed Iraqi, Avishay Edri, Yariv Greenshpan, Kiran Kundu, Priyanka Bolel, Avishag Cahana, Aner Ottolenghi, Roi Gazit, Leslie Lobel, Alex Braiman, Angel Porgador
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Ab—antibody
EBOV—ebola virus
GP—glycoprotein
N-glycosylation
immune evasion
steric shielding
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00048/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2020.00048/full

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