Depletion of LncRNA NEAT1 Rescues Mitochondrial Dysfunction Through NEDD4L-Dependent PINK1 Degradation in Animal Models of Alzheimer’s Disease

Depletion of LncRNA NEAT1 Rescues Mitochondrial Dysfunction Through NEDD4L-Dependent PINK1 Degradation in Animal Models of Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common neurodegenerative disorder and the main cause of dementia among the elderly worldwide. Unfortunately, the mechanism of AD remains unclear, and no effective therapies are available yet. An increasing amount of studies have demonstrated that long non-coding...

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Bibliographic Details
Main Authors: Zhonghua Huang, Jing Zhao, Wei Wang, Jun Zhou, Jie Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
NEAT1
Alzheimer’s disease
PINK1
autophagy
NEDD4L
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00028/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00028/full

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