An integrated characterization of contractile, electrophysiological, and structural cardiotoxicity of Sophora tonkinensis Gapnep. in human pluripotent stem cell-derived cardiomyocytes

An integrated characterization of contractile, electrophysiological, and structural cardiotoxicity of Sophora tonkinensis Gapnep. in human pluripotent stem cell-derived cardiomyocytes

Abstract Background Cardiotoxicity remains an important concern in drug discovery and clinical medication. Meanwhile, Sophora tonkinensis Gapnep. (S. tonkinensis) held great value in the clinical application of traditional Chinese medicine, but cardiotoxic effects were reported, with matrine, oxymat...

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Bibliographic Details
Main Authors: Ruiying Wang, Min Wang, Shan Wang, Ke Yang, Ping Zhou, Xueheng Xie, Qi Cheng, Jingxue Ye, Guibo Sun, Xiaobo Sun
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Stem Cell Research & Therapy
Subjects:
Cardiotoxicity
Sophora tonkinensis
hiPSC-CMs
Cardio-NLCS
Online Access:http://link.springer.com/article/10.1186/s13287-018-1126-4

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http://link.springer.com/article/10.1186/s13287-018-1126-4

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