RNA pathogenesis via Toll-like receptor-activated inflammation in expanded repeat neurodegenerative diseases

RNA pathogenesis via Toll-like receptor-activated inflammation in expanded repeat neurodegenerative diseases

Repeat sequences that are expanded in copy number are the basis for ~20 dominantly inherited neurodegenerative diseases, including Huntington’s Disease. Despite some of the responsible genes being identified as long as 20 years ago, the identity and nature of the disease-causing pathogenic pathway r...

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Bibliographic Details
Main Authors: Robert Ian Richards, Saumya eSamaraweera, Clare evan Eyk, Louise Veronica O'Keefe, Catherine eSuter
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neurodegeneration
Toll-like receptor
RNA pathogenesis
Innate inflammation
expanded repeat diseases
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2013.00025/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2013.00025/full

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