Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress

Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress

Abstract Endoplasmic reticulum (ER) stress, caused by the accumulation of unfolded proteins, is involved in the development of obesity. We demonstrated that flurbiprofen, a nonsteroidal anti‐inflammatory drug (NSAID), exhibited chaperone activity, which reduced protein aggregation and alleviated ER...

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Bibliographic Details
Main Authors: Toru Hosoi, Rie Yamaguchi, Kikuko Noji, Suguru Matsuo, Sachiko Baba, Keisuke Toyoda, Takahiro Suezawa, Takaaki Kayano, Shinpei Tanaka, Koichiro Ozawa
Format: Article
Language:English
Published: Wiley 2014-03-01
Series:EMBO Molecular Medicine
Subjects:
STAT3
aldehyde dehydrogenase
nonsteroidal anti‐inflammatory drug
Online Access:https://doi.org/10.1002/emmm.201303227

Internet

https://doi.org/10.1002/emmm.201303227

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