A knock-in reporter mouse model for Batten disease reveals predominant expression of Cln3 in visual, limbic and subcortical motor structures

A knock-in reporter mouse model for Batten disease reveals predominant expression of Cln3 in visual, limbic and subcortical motor structures

Juvenile neuronal ceroid lipofuscinosis (JNCL) or Batten disease is an autosomal recessive neurodegenerative disorder of children caused by mutation in CLN3. JNCL is characterized by progressive visual impairment, cognitive and motor deficits, seizures and premature death. Information about the loca...

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Bibliographic Details
Main Authors: Song-Lin Ding, Luis Tecedor, Colleen S. Stein, Beverly L. Davidson
Format: Article
Language:English
Published: Elsevier 2011-02-01
Series:Neurobiology of Disease
Subjects:
CLN3
Neuronal ceroid lipofuscinosis
JNCL
Thalamus
Hippocampal formation
Red nucleus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110003128

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http://www.sciencedirect.com/science/article/pii/S0969996110003128

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