Evaluation of Antiproliferative Palladium(II) Complexes of Synthetic Bisdemethoxycurcumin towards In Vitro Cytotoxicity and Molecular Docking on DNA Sequence

Evaluation of Antiproliferative Palladium(II) Complexes of Synthetic Bisdemethoxycurcumin towards In Vitro Cytotoxicity and Molecular Docking on DNA Sequence

Metallodrugs form a large family of therapeutic agents against cancer, among which is cisplatin, a paradigmatic member. Therapeutic resistance and undesired side effects to Pt(II) related drugs, prompts research on different metal–ligand combinations with potentially enhanced biological activity. We...

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Bibliographic Details
Main Authors: Natalia Miklášová, Peter Herich, Juan Carlos Dávila-Becerril, Joaquín Barroso-Flores, Eva Fischer-Fodor, Jindra Valentová, Janka Leskovská, Jozef Kožíšek, Peter Takáč, Ján Mojžiš
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
palladium(II) complexes
synthetic bisdemethoxycurcumin
cytotoxicity
DNA-binding
HSA binding
transcription factor NF-κB
Online Access:https://www.mdpi.com/1420-3049/26/14/4369

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https://www.mdpi.com/1420-3049/26/14/4369

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