Attenuation of Native Hyperpolarization-Activated, Cyclic Nucleotide-Gated Channel Function by the Volatile Anesthetic Sevoflurane in Mouse Thalamocortical Relay Neurons

Attenuation of Native Hyperpolarization-Activated, Cyclic Nucleotide-Gated Channel Function by the Volatile Anesthetic Sevoflurane in Mouse Thalamocortical Relay Neurons

As thalamocortical relay neurons are ascribed a crucial role in signal propagation and information processing, they have attracted considerable attention as potential targets for anesthetic modulation. In this study, we analyzed the effects of different concentrations of sevoflurane on the excitabil...

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Bibliographic Details
Main Authors: Stefan Schwerin, Claudia Kopp, Elisabeth Pircher, Gerhard Schneider, Matthias Kreuzer, Rainer Haseneder, Stephan Kratzer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
sevoflurane
thalamus
thalamocortical relay neurons
HCN channel
mechanisms of anesthesia
patch-clamp
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.606687/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2020.606687/full

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