Activating Mutations in <i>PTPN11</i> and <i>KRAS</i> in Canine Histiocytic Sarcomas

Activating Mutations in <i>PTPN11</i> and <i>KRAS</i> in Canine Histiocytic Sarcomas

While the genetic contributions to the predisposition of Bernese mountain dogs (BMDs) to histiocytic sarcoma (HS) remains unclear, some insights into key genetic drivers have been gained. Our group recently reported a mutation in the <i>PTPN11</i> gene (E76K). We have now identified a se...

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Bibliographic Details
Main Authors: Marilia Takada, Lauren A. Smyth, Tuddow Thaiwong, Marlee Richter, Sarah M. Corner, Peter Z. Schall, Matti Kiupel, Vilma Yuzbasiyan-Gurkan
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Genes
Subjects:
Bernese mountain dog
histiocytic sarcoma
<i>PTPN11</i>
<i>KRAS</i>
somatic mutation
Online Access:https://www.mdpi.com/2073-4425/10/7/505

Internet

https://www.mdpi.com/2073-4425/10/7/505

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