The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis

The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis

The prohormone VGF is expressed in neuroendocrine and endocrine tissues and regulates nutrient and energy status both centrally and peripherally. We and others have shown that VGF-derived peptides have direct action on the islet β cell as secretagogues and cytoprotective agents; however, the endogen...

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Bibliographic Details
Main Authors: Samuel B. Stephens, Robert J. Edwards, Masato Sadahiro, Wei-Jye Lin, Cheng Jiang, Stephen R. Salton, Christopher B. Newgard
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
VGF
secretory granule
insulin secretion
granule biogenesis
chromogranin B
β cell function
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311750

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http://www.sciencedirect.com/science/article/pii/S2211124717311750

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