Neutrophil elastase mediates acute pathogenesis and is a determinant of long-term behavioral recovery after traumatic injury to the immature brain

While neutrophil elastase (NE), released by activated neutrophils, is a key mediator of secondary pathogenesis in adult models of brain ischemia and spinal cord injury, no studies to date have examined this protease in the context of the injured immature brain, where there is notable vulnerability r...

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Bibliographic Details
Main Authors: Bridgette D. Semple, Alpa Trivedi, Kayleen Gimlin, Linda J. Noble-Haeusslein
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611400374X