Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

Abstract Background TREM2 is an innate immune receptor specifically expressed in microglia. Coding variations in TREM2 have been reported to increase the risk for Alzheimer’s disease (AD) and other neurodegenerative diseases. While multiple studies support a role for TREM2 in microglial recruitment...

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Bibliographic Details
Main Authors: Li Zhong, Zongqi Wang, Daxin Wang, Zhe Wang, Yuka A. Martens, Linbei Wu, Ying Xu, Kai Wang, Jianguo Li, Ruizhi Huang, Dan Can, Huaxi Xu, Guojun Bu, Xiao-Fen Chen
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Molecular Neurodegeneration
Subjects:
β-amyloid
microglia
migration
TREM2
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s13024-018-0247-7

Internet

http://link.springer.com/article/10.1186/s13024-018-0247-7

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