A Monoclonal Antibody Combination against both Serotypes A and B Botulinum Toxin Prevents Inhalational Botulism in a Guinea Pig Model

A Monoclonal Antibody Combination against both Serotypes A and B Botulinum Toxin Prevents Inhalational Botulism in a Guinea Pig Model

Botulinum neurotoxins (BoNT) are extremely potent and can induce respiratory failure, requiring long-term intensive care to prevent death. Recombinant monoclonal antibodies (mAbs) hold considerable promise as BoNT therapeutics and prophylactics. In contrast, equine antitoxin cannot be used prophylac...

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Bibliographic Details
Main Authors: Doris M. Snow, Ronald R. Cobb, Juan Martinez, Isaac Finger-Baker, Laura Collins, Sara Terpening, Emily S. Syar, Nancy Niemuth, Dean Kobs, Roy Barnewall, Shauna Farr-Jones, James D. Marks, Milan T. Tomic
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Toxins
Subjects:
botulinum neurotoxin
aerosol
monoclonal antibody
guinea pig inhalation model
oligoclonal antibody
botulism
Online Access:https://www.mdpi.com/2072-6651/13/1/31

Internet

https://www.mdpi.com/2072-6651/13/1/31

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