Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift

Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift

It is firmly believed that the mechanism of action of SSRIs in major depression is to inhibit the serotonin transporter, SERT, and increase extracellular concentration of serotonin. However, this undisputed observation does not prove that SERT inhibition is the mechanism, let alone the only mechanis...

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Bibliographic Details
Main Authors: Leif eHertz, Douglas l Rothman, Baoman eLi, Liang ePeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Glycogen
calcium homeostasis
major depression
glucose metabolism;
PLA2
fluoxetine signaling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00025/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00025/full

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