Evaluation of the sublingual route for administration of influenza H5N1 virosomes in combination with the bacterial second messenger c-di-GMP.

Avian influenza A H5N1 is a virus with pandemic potential. Mucosal vaccines are attractive as they have the potential to block viruses at the site of entry, thereby preventing both disease and further transmission. The intranasal route is safe for the administration of seasonal live-attenuated influ...

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Bibliographic Details
Main Authors: Gabriel Kristian Pedersen, Thomas Ebensen, Ingrid Hjetland Gjeraker, Signe Svindland, Geir Bredholt, Carlos Alberto Guzmán, Rebecca Jane Cox
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22069479/pdf/?tool=EBI