Chromatin accessibility promotes hematopoietic and leukemia stem cell activity

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity

Chromatin accessibility is a key mediator of gene expression and mutations in chromatin modifiers are frequently seen in cancers. Here, the authors show that the chromatin accessibility regulator HMGN1 - which is frequently mutated by amplification in leukemias - acts by blocking myeloid differentia...

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Bibliographic Details
Main Authors: Lucia Cabal-Hierro, Peter van Galen, Miguel A. Prado, Kelly J. Higby, Katsuhiro Togami, Cody T. Mowery, Joao A. Paulo, Yingtian Xie, Paloma Cejas, Takashi Furusawa, Michael Bustin, Henry W. Long, David B. Sykes, Steven P. Gygi, Daniel Finley, Bradley E. Bernstein, Andrew A. Lane
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15221-z

Internet

https://doi.org/10.1038/s41467-020-15221-z

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