Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors.

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors.

Autophagy, particularly with BECN1, has paradoxically been highlighted as tumor promoting in Ras-driven cancers, but potentially tumor suppressing in breast and ovarian cancers. However, studying the specific role of BECN1 at the genetic level is complicated due to its genomic proximity to BRCA1 on...

Full description

Bibliographic Details
Main Authors: Joe R Delaney, Chandni B Patel, Jaidev Bapat, Christian M Jones, Maria Ramos-Zapatero, Katherine K Ortell, Ralph Tanios, Mina Haghighiabyaneh, Joshua Axelrod, John W DeStefano, Isabelle Tancioni, David D Schlaepfer, Olivier Harismendy, Albert R La Spada, Dwayne G Stupack
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008558

Internet

https://doi.org/10.1371/journal.pgen.1008558

Similar Items