Elimination of intravascular thrombi prevents early mortality and reduces gliosis in hyper-inflammatory experimental cerebral malaria

Elimination of intravascular thrombi prevents early mortality and reduces gliosis in hyper-inflammatory experimental cerebral malaria

Abstract Background Cerebral malaria (CM) is the most lethal outcome of Plasmodium infection. There are clear correlations between expression of inflammatory cytokines, severe coagulopathies, and mortality in human CM. However, the mechanisms intertwining the coagulation and inflammation pathways, a...

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Bibliographic Details
Main Authors: Kyle D. Wilson, Lorenzo F. Ochoa, Olivia D. Solomon, Rahul Pal, Sandra M. Cardona, Victor H. Carpio, Philip H. Keiser, Astrid E. Cardona, Gracie Vargas, Robin Stephens
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Journal of Neuroinflammation
Subjects:
Malaria
Brain
Inflammation
Neuropathology
Vascular congestion
Monocyte
Online Access:http://link.springer.com/article/10.1186/s12974-018-1207-4

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http://link.springer.com/article/10.1186/s12974-018-1207-4

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