Aberrant Glycosylation Augments the Immuno-Stimulatory Activities of Soluble Calreticulin
Calreticulin (CRT), a luminal resident calcium-binding glycoprotein of the cell, is a tumor-associated antigen involved in tumorigenesis and also an autoantigen targeted by autoantibodies found in patients with various autoimmune diseases. We have previously shown that prokaryotically expressed reco...
Main Authors: | Fang-Yuan Gong, Zheng Gong, Cui-Cui Duo, Jun Wang, Chao Hong, Xiao-Ming Gao |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-02-01
|
Series: | Molecules |
Subjects: | |
Online Access: | http://www.mdpi.com/1420-3049/23/3/523 |
Similar Items
-
The role of calnexin, calreticulin and heavy chain glycosylation in MHC class I assembly
by: Adhikari, Raju
Published: (2002) -
Soluble Calreticulin Induces Tumor Necrosis Factor-α (TNF-α) and Interleukin (IL)-6 Production by Macrophages through Mitogen-Activated Protein Kinase (MAPK) and NFκB Signaling Pathways
by: Cui-Cui Duo, et al.
Published: (2014-02-01) -
A Roadmap for the Molecular Farming of Viral Glycoprotein Vaccines: Engineering Glycosylation and Glycosylation-Directed Folding
by: Emmanuel Margolin, et al.
Published: (2020-12-01) -
Calreticulin Blockade Attenuates Murine Acute Lung Injury by Inducing Polarization of M2 Subtype Macrophages
by: Zhilong Jiang, et al.
Published: (2020-01-01) -
Surface-exposed and soluble calreticulin: conflicting biomarkers for cancer prognosis
by: Oliver Kepp, et al.
Published: (2020-01-01)