Obeticholic Acid Inhibits Anxiety Via Alleviating Gut Microbiota-Mediated Microglia Accumulation in the Brain of High-Fat High-Sugar Diet Mice

Obeticholic Acid Inhibits Anxiety Via Alleviating Gut Microbiota-Mediated Microglia Accumulation in the Brain of High-Fat High-Sugar Diet Mice

Anxiety is one of the complications of metabolic disorders (MDs). Obeticholic acid (OCA), the bile acids (BAs) derivative, is a promising agent for improving MDs in association with gut dysbiosis. Yet, its protective effect on MDs-driven anxiety remains unknown. Here, we assessed the serum biochemic...

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Bibliographic Details
Main Authors: Li Wu, Yuqiu Han, Zhipeng Zheng, Shuai Zhu, Jun Chen, Yuanyuan Yao, Siqing Yue, Andreas Teufel, Honglei Weng, Lanjuan Li, Baohong Wang
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Nutrients
Subjects:
obeticholic acid
anxiety
gut microbiota
neuroinflammation
bile acids
metabolic disorders
Online Access:https://www.mdpi.com/2072-6643/13/3/940

Internet

https://www.mdpi.com/2072-6643/13/3/940

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