The mammalian lectin galectin-8 induces RANKL expression, osteoclastogenesis, and bone mass reduction in mice

The mammalian lectin galectin-8 induces RANKL expression, osteoclastogenesis, and bone mass reduction in mice

Skeletal integrity is maintained by the co-ordinated activity of osteoblasts, the bone-forming cells, and osteoclasts, the bone-resorbing cells. In this study, we show that mice overexpressing galectin-8, a secreted mammalian lectin of the galectins family, exhibit accelerated osteoclasts activity a...

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Bibliographic Details
Main Authors: Yaron Vinik, Hadas Shatz-Azoulay, Alessia Vivanti, Navit Hever, Yifat Levy, Rotem Karmona, Vlad Brumfeld, Saja Baraghithy, Malka Attar-Lamdar, Sigalit Boura-Halfon, Itai Bab, Yehiel Zick
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-05-01
Series:eLife
Subjects:
animal lectin
osteoclastogenesis
bone mass
Online Access:https://elifesciences.org/articles/05914

Internet

https://elifesciences.org/articles/05914

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