15-epi-lipoxin A4 inhibits TNF-α-induced tissue factor expression via the PI3K/AKT/ NF-κB axis in human umbilical vein endothelial cells

15-epi-lipoxin A4 inhibits TNF-α-induced tissue factor expression via the PI3K/AKT/ NF-κB axis in human umbilical vein endothelial cells

Inflammation and coagulation are two important processes implicated in venous thromboembolism (VTE). 15-epi-lipoxin A4 (15-epi-LXA4) is the epimer of LXA4, a small lipid molecule, is known to play a key role in the resolution of inflammation. This study aimed to demonstrate whether 15-epi-LXA4 could...

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Bibliographic Details
Main Authors: Yijian Chen, Yongliang Zheng, Liuyan Xin, Sisi Zhong, Aifei Liu, Wenhong Lai, Liping Liu, Chuanming Lin, Changfeng Liao, Junquan Zeng, Liqun Zhang
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
15-epi-lipoxin A4
Tumor necrosis factor-alpha
Tissue factor
PI3K/AKT signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219311576

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http://www.sciencedirect.com/science/article/pii/S0753332219311576

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