The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer

The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer

Abstract Background The role of tumor protein D54 in breast cancer has not been studied and its function in breast cancer remains unclear. In our previous pharmacogenomic studies using lymphoblastoid cell line (LCL), this protein has been identified to affect metformin response. Although metformin h...

Full description

Bibliographic Details
Main Authors: Yongxian Zhuang, Reynold C. Ly, Carleigh V. Frazier, Jia Yu, Sisi Qin, Xiao-Yang Fan, Matthew P. Goetz, Judy C. Boughey, Richard Weinshilboum, Liewei Wang
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Cancer & Metabolism
Subjects:
Tumor protein D54 (TPD54)
Pyruvate dehydrogenase (PDH)
Pyruvate dehydrogenase kinase (PDK)
Metformin
Mitochondrial reactive oxygen species (ROS)
Online Access:http://link.springer.com/article/10.1186/s40170-018-0193-4

Internet

http://link.springer.com/article/10.1186/s40170-018-0193-4

Similar Items