Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy

Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy

Compromised autophagy and mitochondrial dysfunction downregulate chondrocytic activity, accelerating the development of osteoarthritis (OA). Irisin, a cleaved form of fibronectin type III domain containing 5 (FNDC5), regulates bone turnover and muscle homeostasis. Little is known about the effect of...

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Bibliographic Details
Main Authors: Feng-Sheng Wang, Chung-Wen Kuo, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Huei-Jing Ke, Pei-Chen Kuo, Chin-Huei Lee, Jian-Ching Wu, Wen-Bin Lu, Ming-Hong Tai, Holger Jahr, Wei-Shiung Lian
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Antioxidants
Subjects:
chondrocyte
irisin
FNDC5
autophagy
mitochondria
osteoarthritis
Online Access:https://www.mdpi.com/2076-3921/9/9/810

Internet

https://www.mdpi.com/2076-3921/9/9/810

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