Quantitative proteomic profiling of white matter in cases of cerebral amyloid angiopathy reveals upregulation of extracellular matrix proteins and clusterin

Quantitative proteomic profiling of white matter in cases of cerebral amyloid angiopathy reveals upregulation of extracellular matrix proteins and clusterin

Aims: Cerebral amyloid angiopathy (CAA) is the accumulation of amyloid beta (Aβ) in the walls of cerebral arterioles, arteries and capillaries. Changes in the white matter in CAA are observed as hyperintensities and dilated perivascular spaces on MRI suggesting impairment of fluid drainage but the p...

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Bibliographic Details
Main Authors: Antigoni Manousopoulou, Ho Ming Yuen, Matt MacGregor Sharp, Satoshi Saito, Roxana Aldea, Norman Mazer, Spiros D Garbis, Roxana O Carare
Format: Article
Language:English
Published: University of Münster / Open Journals System 2020-10-01
Series:Free Neuropathology
Subjects:
extracellular matrix
cell adhesion
clusterin
cerebral amyloid angiopathy
caa
white matter
proteomics
Online Access:https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/2955

Internet

https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/2955

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