HMGB1 attenuates cardiac remodelling in the failing heart via enhanced cardiac regeneration and miR-206-mediated inhibition of TIMP-3.

HMGB1 attenuates cardiac remodelling in the failing heart via enhanced cardiac regeneration and miR-206-mediated inhibition of TIMP-3.

AIMS: HMGB1 injection into the mouse heart, acutely after myocardial infarction (MI), improves left ventricular (LV) function and prevents remodeling. Here, we examined the effect of HMGB1 in chronically failing hearts. METHODS AND RESULTS: Adult C57 BL16 female mice underwent coronary artery ligati...

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Bibliographic Details
Main Authors: Federica Limana, Grazia Esposito, Daniela D'Arcangelo, Anna Di Carlo, Sveva Romani, Guido Melillo, Antonella Mangoni, Chiara Bertolami, Giulio Pompilio, Antonia Germani, Maurizio C Capogrossi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3120764?pdf=render

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http://europepmc.org/articles/PMC3120764?pdf=render

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