Atypical seizure-like activity in cortical reverberating networks in-vitro can be caused by LPS-induced inflammation: a multi-electrode array study from a hundred neurons

Atypical seizure-like activity in cortical reverberating networks in-vitro can be caused by LPS-induced inflammation: a multi-electrode array study from a hundred neurons

We show here that a mild sterile inflammation induced by the endotoxin lipopolysaccharide (LPS), in a neuron/astrocyte/microglial cortical network, modulates neuronal excitability and can initiate long-duration burst events resembling epileptiform seizures, a recognized feature of various central ne...

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Bibliographic Details
Main Authors: Francesca eGULLO, Alida eAmadeo, Giulia eDonvito, Marzia eLecchi, Barbara eCosta, Andrew eConstanti, Enzo eWanke
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Minocycline
LPS
burst firing
neocortical cultures
Sterile Inflammation
TNF-α
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00361/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00361/full

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