B1 Cell IgE Impedes Mast Cell-Mediated Enhancement of Parasite Expulsion through B2 IgE Blockade

B1 Cell IgE Impedes Mast Cell-Mediated Enhancement of Parasite Expulsion through B2 IgE Blockade

Summary: Helminth infection is known for generating large amounts of poly-specific IgE. Here we demonstrate that innate-like B1 cells are responsible for this IgE production during infection with the nematode parasites Nippostrongylus brasiliensis and Heligmosomoides polygyrus bakeri. In vitro analy...

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Bibliographic Details
Main Authors: Rebecca K. Martin, Sheela R. Damle, Yolander A. Valentine, Matthew P. Zellner, Briana N. James, Joseph C. Lownik, Andrea J. Luker, Elijah H. Davis, Martha M. DeMeules, Laura M. Khandjian, Fred D. Finkelman, Joseph F. Urban, Jr., Daniel H. Conrad
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Subjects:
helminth
B1 cells
B2 cells
mast cells
Th2
N. brasiliensis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718300809

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http://www.sciencedirect.com/science/article/pii/S2211124718300809

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